Best route of antibiotics administrations?

Many clinicians believe that antibiotics i.v administrations is the best route in serious infections. Bioavailability of that route is nearly perfect, one. But not all i.v. route is the best route for an example Levofloxacin orally shows bioavailability 99%.
Continous versus intermittent bolus i.v infusion
Continous bolus i.v infusion may decrease risk of vein irritation and phlebitis. Suitable for time dependent bactericidal activity such as beta-lactams and vancomycin. Intermittent i.v. infusion, suitable for concentration dependent bactericidal activity, such as aminoglycosides and fluoroquinolons. Keeping drugs above MIC with little additional dose of drugs.

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