Wednesday, March 11, 2009

Best route of antibiotics administrations?

Many clinicians believe that antibiotics i.v administrations is the best route in serious infections. Bioavailability of that route is nearly perfect, one. But not all i.v. route is the best route for an example Levofloxacin orally shows bioavailability 99%.
Continous versus intermittent bolus i.v infusion
Continous bolus i.v infusion may decrease risk of vein irritation and phlebitis. Suitable for time dependent bactericidal activity such as beta-lactams and vancomycin. Intermittent i.v. infusion, suitable for concentration dependent bactericidal activity, such as aminoglycosides and fluoroquinolons. Keeping drugs above MIC with little additional dose of drugs.

Monday, March 9, 2009

The role of clinical microbiology specialist

According to Prof. Henri A Verbrugh, a Clinical microbiologist and infectious diseases Erasmus University Rotterdam Holland explanation, there are, at least seven roles of clinical microbiology specialist, they are:
1. Professional leader in clinical microbiology laboratory
2. Expert consultant in infectious diseases, giving advices to other colleagues in diagnostics, teraphy and preventions
3. Good manager in many area of budgeting, human resources etc
4. Professional stimulator, part of Hospital wide committee especially in: infection control and antibiotics committee
5. Liaison officer for Public Health issues especially in communicable diseases : epidemiology and travels of diseases
6. Contribute to the advancement of clinical professional research, basic and applied researches
7. Education for next generation for infection control and clinical microbiology
In clinical setting, according to Prof. Kuntaman a clinical microbiologist Airlangga University Surabaya role number two is graded in at least two classes as follow:
Diagnostic and Consultative.

Tuesday, March 3, 2009

Antibiotics usage guidelines

Antibiotics known as chemotherapy against bacteria. There are many antibiotics usage guidelines launched by either private hospitals, public hospitals, divisions or department to treat infectious diseases. There are many ways to develop an antibiotics usage guidelines, such as adaptation from other developed guidelines from other center, empirical usage of antibiotics and develop according to local pattern of susceptibility test of antibiotics to causing agent. In many centers in Indonesia almost all antibiotics usage guidelines is developed through adaptation. What clinical microbiologist can do about this?